1 In the REIMAGINE 2 trial, the most commonly reported AEs were GI-related, occurring in 405/603 (67.2%) participants in the CagriSema 2.4 mg/2.4 mg group, 326/605 (53.9%) participants in the semaglutide 2.4 mg group, 60/152 (39.5%) participants in the cagrilintide 2.4 mg group, 329/594 (55.4%) participants in the CagriSema 1 mg/1 mg group, 288/608 (47.4%) participants in the semaglutide 1 mg group, and 42/149 (28.2%) participants in the placebo group
This affects vital organelles such as mitochondria, causing alterations in the biophysical properties of the membrane, disrupting the electron transport chain activities, decreased fluidity, and subsequently an energy imbalance
Miwa et al., 2014
Composed of glutamic acid, cysteine, and glycine, glutathione plays a critical role in maintaining redox balance, supporting detoxification processes, and protecting cells from oxidative stress
The FDA considers it a non-toxic substance under the Generally Recognized as Safe (GRAS) classification for specific applications
G.NebertD
